名古屋市立大学
なごや先端研究開発センター
温度生物学研究室

Fan J, Ke H, Lei J, Wang J, Tominaga M, Lei X.

Structure basis of TRPV1 inhibition by SAF312 and cholesterol.

DOI: 10.1038/s41467-024-51085-3

Suito T, Tominaga M.

Functional relationship between peripheral thermosensation and behavioral thermoregulation.(Review)

DOI: 10.3389/fncir.2024.1435757

Kashio M, Derouiche S K, Yoshimoto RU, Sano K, Lei J, Kido MA, Tominaga M.

Involvement of TRPV4 in temperature-dependent perspiration in mice.

DOI: 10.7554/eLife.92993.

Takayama Y, Tominaga M.

Interaction between TRP channels and anoctamins. (Review)

DOI: 10.1016/j.ceca.2024.102912

Lei J, Tominaga M.

Ujisawa T, Lei J, Kashio M, Tominaga M.

Thermal Gradient Ring for analysis of temperature-dependent behaviors involving TRP channels in mice. (Review)

DOI: 10.1186/s12576-024-00903-w

Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X.

Structural pharmacology of TRPV4 antagonists.

DOI: 10.1002/advs.202401583

Guo Z, Murakami M, Saito K, Kato H, Toriyama M, Tominaga M, Ishii KJ, Fujita F.

Integrin α5 regulates motility of human monocyte-derived Langerhans cells during immune response.

DOI: 10.1111/exd.15021

Ohnishi K, Sokabe T, Miura T, Tominaga M, Ohta A, Kuhara A.

G protein-coupled receptor determines temperature acclimatization of Caenorhabditis elegans.

DOI: 10.1038/s41467-024-46042-z

Takayama Y, Tominaga M.

Phosphorylated TRPV1 and ANO1/TMEM16A interaction induced by low concentration of capsaicin or innocuous heat stimulation.

DOI: 10.11154/pain.39.1

Kashio M, Tominaga M.

Role of novel de novo gain-of-function TRPM3 mutations in a spectrum of neurodevelopmental disorders. (Review)

DOI: 10.1016/j.ceca.2023.102704

Sato S, Magaji AM, Tominaga M, Sokabe T.

Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs in Drosophila.

DOI: 10.3389/fnmol.2023.1249715

Lei J, Yoshimoto RU, Matsui T, Amagai M, Kido MA, Tominaga M.

Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.

DOI: 10.1038/s41467-023-39712-x

Matsumoto K, Kamide M, Uchida K, Takahata M, Shichiri R, Hida Y, Taniguchi Y, Ohishi A, Tominaga M, Nagasawa K, Kato S.

Transient Receptor Potential Ankyrin 1 in Taste Nerve Contributes to the Sense of Sweet Taste in Mice.

DOI: 10.1248/bpb.b23-00091

Shimizu T, Fujii T, Hanita K, Shinozaki R, Takamura Y, Suzuki Y, Kageyama T, Kato M, Nishijo H, Tominaga M, Sakai H.

Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine.

DOI: 10.1038/s41598-023-31322-3

Saito KO, Fujita F, Toriyama M, Utami RA, Guo Z, Myrakami M, Kato H, Suzuki Y, Okada F, Tominaga M, Ishii KJ.

Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent.

DOI: 10.1016/j.bbrc.2023.02.062

Yamanoi Y, Lei J, Takayama Y, Hosogi S, Marunaka Y, Tominaga M.

TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes.

DOI: 10.1038/s42003-023-04482-1

Atsumi Y, Toriyama M, Kato H, Nakamura M1,4, Morita A, Okada F, Tominaga M, Ishii K, Fujita F.

Anti-inflammatory role of TRPV4 in human macrophages.

DOI: 10.4049/immunohorizons.2200100

Kashio M, Tominaga M.

TRP channels in thermosensation. (Review)

DOI: 10.1016/j.conb.2022.102591

Boudaka A, Tominaga M.

Physiological and pathological significance of esophageal TRP channels: Specific focus on TRPV4 in esophageal epithelial cells. (Review)

DOI: 10.3390/ijms23094550

Sokabe T, Bradshaw HB, Tominaga M, Leishman E, Chandel A, Montell C.

Endocannabinoids produced in photoreceptor cells in response to lightactivate Drosophila TRP channels.

DOI: 10.1126/scisignal.abl6179

Sugino S, Inoue K, Kobayashi R, Hirose R, Doi T, Harusato A, Dohi O, Yoshida N, Uchiyama K, Ishikawa T, Takagi T, Yasuda H, Konishi H, Hirai Y, Mizushima K, Naito Y, Tsuji T, Okuda T, Kagawa K, Tominaga M, Itoh Y.

Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model.

DOI: 10.5056/jnm21198

Kashio M, Masubuchi S, Tominaga M.

Protein kinase C-mediated phosphorylation of transient receptor potential melastatin type 2 Thr738 counteracts the effect of cytosolic Ca2+ and elevates the temperature threshold.

DOI: 10.1113/JP283350

Saito S, Saito CT, Igawa T, Takeda N, Komaki S, Ohta T, Tominaga M.

Evolutionary tuning of TRPA1 underlies the variation in heat avoidance behaviors among frog species inhabiting diverse thermal niches.

DOI: 10.1093/molbev/msac180

Yoshimura A, Saito S, Saito CT, Takahashi K, Tominaga M, Ohta T.

Functional analysis of thermos-sensitive TRPV1 in an aquatic vertebrate, mas salmon (Oncorhynchus masou ishikawae).

DOI: 10.1016/j.bbrep.2022.101315

Nguyen THD, Chapman S, Kashio M, Saito C, Strom T, Yasui M, Tominaga M.

Single amino acids set apparent temperature thresholds for heat-evoked activation of mosquito transient receptor potential channel TRPA1.

DOI: 10.1016/j.jbc.2022.102271

Sasajima S, Kondo M, Ohno N, Ujisawa T, Motegi M, Hayami T, Asano S, Asano-Hayami E, Nakai-Shimoda H, Inoue R, Yamada Y, Miura-Yura E, Morishita Y, Himeno T, Tsunekawa S, Kato Y, Nakamura J, Kamiya H, Tominaga M.

Thermal Gradient Ring Reveals Thermosensory Changes in Diabetic Peripheral Neuropathy in Mice.

DOI: 10.1038/s41598-022-14186-x

Ujisawa T, Sasajima S, Kashio M, Tominaga M.

Thermal Gradient Ring Reveals Different Temperature-dependent Behaviors in Mice Lacking Thermosensitive TRP Channels.

DOI: 10.1186/s12576-022-00835-3

Nakamura T, Sakamoto J, Okabe K, Taniguchi A, Yamada TG, Nonaka S, Kamei Y, Funahashi A, Tominaga M, Hiroi NF.

Temperature elevation detection in migrating cells.

DOI: 10.1364/OPTCON.453885

Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, Horiguchi T.

The mechanism of pertussis cough revealed by the mouse-coughing model.

DOI: 10.1128/mbio.01446-22

Sugisawa E, Kondo T, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa E, Takemura N, Hayashi Y, Sasaki T, Martino MM, Tominaga M, Maruyama K.

Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia.

DOI: 10.1016/j.celrep.2022.110462

Quiroga HPO, Ganassi M, Yokoyama S, Nakamura K, Yamashita T, Raimbach D, Hagiwara A, Harrington O, Breach-Teji J, Asakura A, Suzuki Y, Tominaga M, Zammit PS, Goto K.

Fine tuning of Piezo1 Expression and Activity Ensures Efficient Myoblast Fusion during Skeletal Myogenesis.

DOI: 0.3390/cells11030393

Derouiche S, Li T, Sakai Y, Uta D, Aoyagi S, Tominaga M.

Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva.

DOI: 10.1097/j.pain.0000000000002337

Kasahara Y, Narukawa M, Takeuchi A, Tominaga M, Abe K, Asakura T.

Molecular logic of salt taste reception in special reference to transmembrane channel-like 4 (TMC4). (Review)

DOI: 10.1186/s12576-022-00856-y

Kasahara Y, Narukawa M, Kanda S, Tominaga M, Misaka T, Abe K, Asakura T.

Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste.

DOI: 10.1093/bbb/zbab152.

Fouad A, Matsumoto K, Amagase K, Yasuda H, Tominaga M, Kato S.

Protective Effect of TRPM8 against Indomethacin-Induced Small Intestinal Injury via the Release of Calcitonin Gene-Related Peptide in Mice.

DOI: 10.1248/bpb.b21-00045.

Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Takahashi S, Okada T, Toyooka K, Sharif J, Furuya Y, Abe T, Tominaga M, Miyawaki A, Amagai M.

Unique cell death of keratinocytes, corneoptosis, requires Ca2+ elevation and acidification.

DOI: 10.1073/pnas.2020722118.

Nishimoto R, Derouiche S, Eto K, Deveci A, Kashio M, Kimori Y, Matsuoka Y, Morimatsu H, Nabekura J, Tominaga M.

Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement.

DOI: 10.1073/pnas.2012894118.

Yokoyama T, Saito S, Shimoda M, Kobayashi M, Takasu Y, Sezutsu H, Kato Y, Tominaga M, Mizoguchi A, Shiomi K.

Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms.

DOI: 10.1038/s41598-021-87590-4.

Kobayashi K, Ashina K, Derouiche S, Hamabata T, Nakamura T, Nagata N, Tominaga M, Murata T.

5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid accelerates the healing of colitis by inhibiting transient receptor potential vanilloid 4-mediated signaling.

DOI: 10.1096/fj.201903207RRR.

Nguyen THD, Itoh GS, Okumura H, Tominaga M.

Structural basis for promiscuous action of monoterpenes on TRP channels.

DOI: 10.1038/s42003-021-01776-0.

Uchida K, Kita T, Hatta M, Itoh GS, Okumura H, Tominaga M, Yamazaki J.

Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel.

DOI: 10.1016/j.heliyon.2021.e06102.

Feng X, Song X, Tominaga M.

Physiological significance of TRPV4 channels in non-myelinating Schwann cells. (Review)

DOI: 10.35248/2329-9096.21.9.588

Feng X, Takayama Y, Ohno N, Kanda H, Dai Y, Sokabe T, Tominaga M.

Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury.

DOI: 10.1038/s42003-020-01444-9

Ohnishi K, Saito S, Miura T, Ohta A, Tominaga M, Sokabe T, Kuhara A.

OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation.

DOI: 10.1038/s41598-020-75302-3.

Uzura R, Takahashi K, Saito S, Tominaga M, Ohta T.

Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1.

DOI: 10.1016/j.brainres.2020.147052.

Suzuki Y, Sawada H, Tokumasu T, Suzuki S, Ninomiya S, Shirai M, Mukai T, Saito CT, Nishimura G, Tominaga M.

Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism.

DOI: 10.1186/s12576-020-00761-2

Sugisawa E, Takayama Y, Takemura N, Kondo T, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K.

RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis.

DOI: 10.1016/j.cell.2020.06.022.

Boudaka A, Saito C.T., Tominaga M.

Deletion of TRPV4 Enhances in vitro wound healing of murine esophageal keratinocytes.

DOI: 10.1038/s41598-020-68269-8.

Shimada H, Kusakizako T, Nguyen THD, Nishizawa T, Hino T, Tominaga M, Nureki O.

The structure of nanodisc-reconstituted TRPV3 reveals the lipid-associated gating mechanism.

DOI: 10.1038/s41594-020-0439-z.

Matsumoto K, Deguchi A, Motoyoshi A, Morita A, Maebashi U, Nakamoto T, Kawanishi S, Sueyoshi M, Nishimura K, Takata K, Tominaga M, Nakahara T, Kato S.

Role of transient receptor potential vanilloid 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice.

DOI: 10.1016/j.ejphar.2019.172853.

Shibasaki K, Yamada K, Miwa H, Yanagawa Y, Suzuki M, Tominaga M, Ishizaki Y.

Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation.

DOI: 10.1038/s41374-019-0335-5.

Mihara H, Boudaka A, Tominaga M, Sugiyama T.

Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.

DOI: 10.1159/000504021.